Do they just suddenly wilt and die within a day or two, with no apparent issues beforehand? If so, I'd be thinking about bacterial wilt spread by cucumber beetles. Our favorite cucumber is a European burpless type that is extremely attractive to cucumber beetles, and our plants (grown outside) used to wilt and die after producing only one or two fruits--until we started making sleeves of very lightweight row cover to cover their cages until the female flowers started to bloom. We then removed the sleeves to allow pollination and managed to get a decent crop afterward (because the disease takes time to develop).
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Bitterwort
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