I make lots of crosses every year, some I persue, some I don't. All come from carefully chosen parents. The reason I don't generally just re-grow F1's again and again is that very rarely is the "best" that can come out of a cross. Most of the really interesting tomato genes are recessive. Commercial seed companies love F1's because they can make money selling you something you can't get anywhere else, but there's no downside to developing your own crosses to the point of stability.
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