It will give you variability, but that's not necessarily a bad thing. The genetic variability can actually result in lots of very cool segregates.
Having said that, there are tons of crosses that have been shared on here, including quite a few within the Dwarf Breeding Project, that have included F2 parents, and even F1's.
IMHO, using an early generation cross as a breeding parent can be really fun, especially if you have LOTS of space to grow a ton of plants out.
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I could sail by on the winds of silence, and maybe they won't notice... but this time I think it would be better if I swim..
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