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Tomatillos grow nautrally in Mexico and other South American locales as "weeds" basically and they are everywhere. I have never had any problem getting them to germinate and in about a "second and a half" they outgrow whatever container they are in! I save 2 liter plastic bottles that I cut the tops off of. (like those coke, etc. come in.) I put 2 inches of soil in the bottom, add seeds and cover lightly. Once they germinate, I will keep adding soil until I am at the top of the bottle. In the garden, they are THE WORST sprawlers and I have to tie them up at least every other day (and you have to be careful and not use too fine of twine or it will cut the stalks like butter. They are not as tough as tomato stalk is.) When planted near other stuff, they just irritate me with their garden hogging capabilities!

Virulent re-seeders, either put down plastic under the plants or be dilligent about removing fallen fruit quickly. I have virtually unlimited space so my "'Tillo's" have there own little place quite aways a way from the rest of the garden. They share their garden plot with the other self-perpetuating species like Dill and my husbands Cherry Tomato plants. My husband calls their little plot "Purgatory"HAH!